Vitamin B3 (Nicotinamide/Niacinamide) 500Mg 180 Tablets

Why We Chose This Product

• Nicotinamide is also known as vitamin B3 or niacinamide. 
• It is an essential vitamin in our diets found in meats, seed and nuts. 
• One large study (with 292 patients) found that nicotinamide tablets twice a day increased skin hydration compared to a placebo. It took a long time for the skin hydration to improve though (up to 1 year taking the supplement). 
• The findings were from a study in adults with skin cancer. Nicotinamide tablets haven't been studied specifically for eczema patients.   
• Nicotinamde has been studied as a cream in eczema. One small study showed that nicotinamide cream reduced itch and overall eczema severity compared to standard moisturisers. We recommend nicotinamide creams in our Medicated Moisturiser collection. 
• Nicotinamide also increased ceramides and other lipids (oils) found naturally in the skin. Two small studies showed that nicotinamide cream improves hydration in the skin compared to standard moisturisers. 
• People with eczema are at higher risk of some types of skin cancer. Nicotinamide protects people from developing skin cancer. 
• These tablets are suitable for vegans.
• These tablets don't cause flushing. 

Directions

Ingredients

References

1. Chen AC, Martin AJ, Dalziell RA, Halliday GM, Damian DL. Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial. Br J Dermatol. 2016 Dec;175(6):1363-1365. doi: 10.1111/bjd.14648. Epub 2016 Sep 20. PMID: 27062605.
2. Soma Y, Kashima M, Imaizumi A, Takahama H, Kawakami T, Mizoguchi M. Moisturizing effects of topical nicotinamide on atopic dry skin. Int J Dermatol. 2005 Mar;44(3):197-202. doi: 10.1111/j.1365-4632.2004.02375.x. PMID: 15807725.
3. Zhu JR, Wang J, Wang SS. A single-center, randomized, controlled study on the efficacy of niacinamide-containing body emollients combined with cleansing gel in the treatment of mild atopic dermatitis. Skin Res Technol. 2023 Sep;29(9):e13475. doi: 10.1111/srt.13475. PMID: 37753690; PMCID: PMC10509598.
4. Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S. Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier. Br J Dermatol. 2000 Sep;143(3):524-31. doi: 10.1111/j.1365-2133.2000.03705.x. PMID: 10971324.
5. Zhu Y, Wang H, He J, Yang L, Zhou X, Li Z, Zhou H, Zhao H, Li Y. Atopic Dermatitis and Skin Cancer Risk: A Systematic Review. Dermatol Ther (Heidelb). 2022 May;12(5):1167-1179. doi: 10.1007/s13555-022-00720-2. Epub 2022 Apr 17. PMID: 35430723; PMCID: PMC9110609.
6. Chen AC, Martin AJ, Choy B, Fernández-Peñas P, Dalziell RA, McKenzie CA, Scolyer RA, Dhillon HM, Vardy JL, Kricker A, St George G, Chinniah N, Halliday GM, Damian DL. A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. N Engl J Med. 2015 Oct 22;373(17):1618-26. doi: 10.1056/NEJMoa1506197. PMID: 26488693.